So, yeah ... GeDoSaTo single-handedly saved Mushihimesama for me
This wasn't doing it for me, my display is 16:10 (1920x1200@60Hz), forcePresentRes stretched the internal 16:9 to 16:10 fullscreen and messed up the aspect ratio, fraps reported 59 and I definitely noticed the missing frame. After some trial and error I ended up with this:
Buttery smooth 60fps, correct aspect ratio in 1200p fullscreen with black bars and face-stabbing sharp sprites.
EDIT: better configs down-thread