I'm worried about they turning all the art style to super deformed because it's more easy on the small screen.Well yeah, I'm not too worried about IP like Zelda or Xenoblade. Those franchises will likely still receive traditional, big budget experiences.
I'm more worried about pretty much everything else, including new IP. As a primarily mobile device, games are going to be tailor made with that in mind. The base station is likely just included to ease the transition out of the home console market. I would have to imagine the vast majority of games will be developed with portability in mind.