So I'm just going to make some notes on details I noticed during watching and rewatching the trailer and I hope people comment on it, it's not all going to be, or at least seem, meaningful, it's just details, many of which have probably been noticed already.
- A leaf fell and some of the leaves are reddened although there is a great deal of green. Could this be a precursor to fall?
-blood splatter on the wall looks like one big hit, cast-off in a single direction (lol what am I? Dexter?) surprise attack maybe?
- Where was Ellie running from? looks like she might have made a left turn as she stepped in that puddle of blood
- The Room Number is 322, obviously this is a secret code announcing the release date somehow. More realistically it suggests the action is in fact taking place inside a hotel, third floor, maybe the Dennison?
- Ellie's clothes are tattered and worn which is to be expected and her hair is dirty but otherwise she seems very well off, only the remnants of a scar on her eyebrow is visible suggesting she is and has been well-protected in this world for some time now but perhaps that wasn't always the case.
- Action moves up to room 424 on the fourth floor.
- There appears to be some sort of emblem or word on the back of not-joel's shirt, I cannot make it out, it might just be a tear in the fabric but it's hard to tell either way.
-Ellie carries a pocket-knife with her but Joel is using an improvised weapon, a piece of wood, to take out not-joel.
- Joel talks about dealing with a buddy and heads screen left, this is away from the room entrance where Ellie came in. Guy in room 322 might not be not-joel's buddy.
- Joel is much bloodier than Ellie, could be from the fight he was just in but there didn't seem to be that much blood involved.
- Ellie's shirt with palm-trees against the sun, what is that shirt?
- not-joel has a broken jaw and some sort of deformity on the side of his face, perhaps first stages of infection
- Ammo scarcity seems to be a real concern, limited shooting
- Joel looks to Ellie for... approval? what? Making sure she's ready, maybe.
- Cordyceps Zombies seem to be alert, able to pick up on the noise from cocking a gun. Suggests that a focus on stealth could be seen in the game?
- Stabbing the 'Zombie' in the back seems to be effective, they feel pain?
- The cars and barbed-wire form a blockade, was this a holdout area? Did Joel and Ellie come here thinking it might be safer?
- Shortly after the cameras pass by the characters we can hear Ellie call our 'Joel!'. What happened? It's followed by two gunshots so it seems maybe the zombies caught up to them?
-The Dennison is outside the blockade area, so they were in a hotel near the Dennison.