i'd love to see them make a setting change that would really piss some people off initially, and make them question whether it was a good idea or not. since the conceit of the series since wind waker has been that this whole "hero of time" thing is a tradition where a new boy wears the clothes on a certain day, you could take it into any era and maintain the general progression of the adventure. imagine if, rather than wind waker/twilight princess's still rather pastoral and undeveloped villages, if link were in a city that was more developed; that way, the transition from link's everyday life to the bizarre, uncontrolled caves, dungeons, etc. that for some reason still lie outside his normal life is a lot more drastic (in much the same way you would be more shocked to find an 800 year old dungeon if you had been raised in nyc).
that's all a hard sell, i know--even to myself. but i think if the series is going to stay really interesting the devs need to step outside the lines a bit