Joker earned $2.4 million on Thursday, bringing its 21-day total to $258.675 million. Presuming it doesn’t drop dead today, it’ll pass Captain America: The Winter Soldier ($259 million in 2014), The Amazing Spider-Man ($262 million in 2012) by tonight. The film had $778 million worldwide as of Wednesday, and it has now earned $788.3 million worldwide. That’ll put it right above Deadpool ($782.6 million in 2016) and Deadpool 2 ($785.05 million in 2018). So, yes, Joker is now the biggest R-rated movie of all time, sans inflation.
Comic book films are dominating on an unprecedented scale, but folks will sample anything as long as it's encased in a DC or Marvel movie.