I LOVE this idea and I would absolutely LOVE a new ME based on this idea if only Bioware could forget about their SJW garbage and get back to making a great Mass Effect again.
So many good stories that can be told from the perspective of humans being the unknown little guys and primitive newcomers to the interstellar community of the galaxy. Star Gate SG1 being a good example. I seem to remember there being some sort of war initially between the humans and the Turians right?