Likely scenario. The game will load the opening movie even if the driver isn't set to Inferno, but setting it to Inferno allows the PSP to load the other cutscenes without issue. So if you aren't getting past the opening loading screen there may be an issue with the ISO you've got. Make sure the unpatched ISOs are fine to begin with.
Repatching in admin mode seems to have done the trick. I apparently didnt run in admin mode the first time.