The thing is it was fine in BIO4/BIO5 given the context--- you were facing humans infected with a parasite with little ability to infect others. But putting your hands all over a literal walking pus-leaking, blood-spewing vessel of a deadly contagion isn't exactly the brightest thing ever.
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Am I the only that notices that you're playing a video game? Who cares? have fun for shits sake.
I love the fact that RE4 is considered the greatest game in existence and everyone praises like it was Jesus's taint on a silver platter. But RE4 is the exact moment that the RE series stopped being about horror and started being Super american manly men saving the world by going to foreign countries and commiting genocide FOR AMERICA! RE4 was pure action and not much horror involved, and when the subsequent games follow the same formula everybody loses their shit.