If they put the NSMB Wii sequel on Wii instead of Cafe, then it would very likely mean that Cafe launches:
-without a Mario game
-without a Mario Kart game
-without a Zelda game
-without a Metroid game
...and with HAL and Sakurai both working on other projects at the moment, it would probably also mean it would launch without a Smash Bros. game.
Didn't Nintendo say they didn't want another system launch without any of their big hitters?
EDIT: I guess they could do Zelda Four Swords Adventures 2/New Legend of Zelda for Cafe.
Why? Nintendo could easily be prepping a Cafe Mario title for late 2012 while a smaller team slaps together a second NSMB title for release this November. A second NSMB game would probably extremely cheap to make and would guarantee a sales boost leading well into 2012. It's a no-brainer.
Do note that Capcom said RE6 will be "totally different" from RE5.
Meh even if there wasn't a pc version it wouldn't be that bad. The PC version of GTAIV is complete and utter trash. Honestly never buying a pc version of anything of Rockstar again unless they can prove that they can properly port games now.