Not really, but Borderlands 3 came out and only the two male characters introduced in Tales were in the game. The game had horrible writing, one character had a completely different personality and weird/dumb story line, and one of the voice actors was changed. The two female characters were completely forgotten about.
People were already not happy about that, and here's another game that either will ignore their characters, or put them in only a minor role. If the game doesn't do well or gets review bombed, I'm sure Gearbox will brush this off as "bigot gamers being mad at our inclusive cast," which is funny considering how many people just them wanted to continue the story with the two black female characters from the first game. Many of them also wanted to see the relationships or romance continue between the characters, and that aspect of things actually was a bit of a cliffhanger.
One other thing. For anyone thinking "Well borderlands games change the main characters with every game," while that is true, it generally does so in the SERVICE of the main characters, not at their expense. The playable characters in standard Borderlands games don't do a lot of talking, so making the first cast of characters NPCs in Borderlands 2 helped flesh out their personalities and continue their stories. For anyone wanting a continuation of the story that was being told, it made a lot of sense to do that with Borderlands 2. It makes no sense to do that in New Tales of the Borderlands.
Actually, Sasha wasn’t forgotten, rather there’s a letter that can be read saying she went missing, and Rhys is trying to figure out what happened. I had hoped a DLC would explore this, but apparently that didn’t happen. Really disappointed that Tales 2 will also ignore this apparently.