This is the answer for me by far. One of the defining moments in gaming as far as I'm concerned. The Bowser fights in Super Mario 64 introduced a completely new way to control a character. Grabing a giant turtle/dragon hybrid by its tail and spinning it fast and furious to send it flying to nearby exploding bombs? Shit blew my mind when I was a kid, and thinking about it now still makes me realize how cool this way to defeat a boss is.
What about you GAF? What have been some of your favorite ways to kill or defeat a boss in a videogame?
Explain your choice