Let's pretend his story is exactly true (I'm not saying it is), then this is the following scenario:
This guy referred to someone as "this person" because he did not know what gender they are
The person then goes on twitter saying that he referred to her as "it" and "thing", specifically knowing she was transgendered and intentionally targeting her
Now, his entire career has been damaged (Microsoft will never hire him again, other companies may get wind of this situation and would have no interest hiring him because of even the hint of taking on bad publicity for no reason), he'll be harassed on public forums in which he needs to use to promote himself, people in his personal life or people in general who know of him may have their opinions of him sullied, and all of this because someone on twitter just flat out lied about him (which is what happened if you take his story at its word). It is an insane amount of damage that shouldn't be swept under the rug. If his story was true, he was harmed big time and the other party is directly responsible and should be held accountable.
Now, it is important to note that I am completely neutral on this matter, have no idea what actually happened, who is right and wrong, am not heavily invested in it either way, and would only be interested in actual factual information as opposed to each party's story. However, the above is all coming from the point of view of the comedian based on his assessment of the situation. IF that is true, then I don't know how you could consider him "low"