Guardians of the Galaxy is extremely similar to Farscape. Bioware has already been heavily drawing inspiration shows like Farscape, Stargate, and Battlestar Galactica, so I don't think GotG really changes the Mass Effect equation much.
It's a great movie, and funny. But Star Lord is basically Crichton, Groot is similar to Zaan, what's his name with the knives is similar to D'argo, Rygel and Rocket are pretty different but are equally small in stature and large in comic relief, and Aeryn and the green girl aren't that different either. Similar art styles too. Star Lord's costume literally looks almost exactly like Crichton's, and they both have ships and hold on to Earth through pop-culture references that no one else gets.
They will probably draw inspiration from GotG too, but that won't change a whole lot.
If you're a GotG fan and haven't seen Farscape, you should check it out.