I would like to see a game with Chloe and Charlie Cutter in the leads. Cutter was funny as hell in Uncharted 3 and deserves more screen time and Chloe is the next best thing after Nathan so my choice would be these two. Actually, I would want to see more from U3, I think that game had a great cast of characters, such as Marlowe and Talbot, Cutter and young Sully. Naughty Dog should explore more of their relationships, seems like they only scratched the surface with these people. I really hope ND doesn´t make a game with Nates daughter, that would be pretty cliché, and quite frankly, boring. The ending in 4 was good but keep it self-contained within the game. Nates arc is over and that should include his nearest family members as well. Let the supporting cast get a chance to shine.