For me, personally, quality over quantity is far more important.
I find Bethseda games, although very fun and enjoyable, to focus a lot more on quantity in regards to where they put their resources.
In an RPG game, I care much more about the story, characters, the interaction and choices you can make that affect other aspects of how the game plays.
I would have gladly traded the ability to pick up plates/forks and other useless junk in previous elder scrolls/fallouts if they instead had smarter AI, better choices and interactivity between npc's and the player, better animation quality, more "unique" dungeons that weren't just copy and pasted.
Give me a town of fewer npc's but each are interactable with their own storyline or at least some dialogue that gives them character and flavor instead of "nameless guard" that says the same 2-3 lines as all the other ones.
At least they are trying to make all the loot "junk" matter in fallout 4 with the crafting aspect, I just hope it works out and it's not an area that falls short.