Honestly, if they cut out the humor elements, it would be a damn good drama. Whoever made the analogy to Breaking Bad on-point. The way BoJack's life spirals down through season 3 is executed very well. I did not think a comedic cartoon could execute the way season three progresses and ends. You're sitting there waiting for the show to bounce back up to being happy after getting increasingly depressing after each episode, but they just let the season end with it lingering at what appears to be rock bottom. No redemption; no nice little bow to end the season. Just despair and a sliver of hope in the last few seconds.
The execution of season 3 bought a lot of goodwill from me. I'm only a couple episodes into season 4, but I'm extremely curious to see how the show progresses character arcs, which is typically something I couldn't care less about when it comes to comedic cartoons/sitcoms.