Kid Icarus Uprising is the best game Nintendo's released since Super Mario Galaxy. Controls are perfect to me. I play without the stand, no pain at all. Same with my casual brother. We both have large hands. We both don't have a problem. Only time I felt soreness was when I first played, I'd play for two hours at a time and holding the system grew a bit uncomforable in the way it did with Super Mario 3D Land. But, I'm not a pussy!
Simply dial horizontal and vertical aiming speed all the way up, in air and on land, and max out reticule stopping speed. Bam! Best controls in any third-person shooter to date, in my honest opinion as a huge action fan (other favorites being Vanquish and Bulletstorm). Nervous twitch gameplay like Unreal Tournament, with a super-tactile feeling thanks to the stylus; melts in your hand and mind so you don't even notice it there, but you feel like you're wielding a sword and physically striking something as you use it, making every battle so impactful, especially online where the game really shows its skill-based depth. Precision and speed, the action fan's bread and butter.
It's like Star Fox 64 with superior scenario, script, production values, depth, gameplay and replayability. The campaign is effectively three arcs in one, like a 26-episode anime OVA; there are ~90 levels of difficulty; over 100 weapons to collect, buy, fuse, and infinite stat modifications; over 400 idols to collect; over 300 in-game achievements, with actual in-game rewards; hours and hours of top-tier voice acting, orchestration, etc; gorgeous graphics and animation; inspired settings and character designs (the level meant to resemble SuperFX Chip graphics ala the original Star Fox was brilliant). Oh, and the best soundtrack Nintendo ever made.
Incredible game. Shame it was so tough for Yahtzee to play. His loss.