It Came From the Desert (Amiga version, others were crap)
This fantastic and well ahead of its time interactive B-Movie adventure game came out in 1989 and was essentially a choose your own adventure (including which of the towns lovely ladies you wanted to romance) with brilliant action sections like first person ant shooting, overhead escape from ants or invasion of ant colony (with full ability to explore the town), flying planes and dropping smoke bombs on ants, playing a game of chicken with local hoodlums, getting into a knife fight with same hoodlums, stealth escape from hospital, real time strategy and more! It also had a fantastic soundtrack!
It Came From The Desert Longplay (listen to the glorious sounds!)
Remade today as a Mass Effect style adventure game where interacting with the townspeople between shooting giant ANTS as the core of the gameplay would be fantastic. Add in some Twin Peaks and X-Files style and B-Movie flavor and you have yourself a hell of a game! Remains one of my favorite games of all time and I still go back and play it once a year. Shame it seems forgotten by most people. Possibly mainly due to it being overlooked in the USA at the time of its release.
Starbreeze recently acquired the Cinemaware catalog, so there is still a chance.
Here is a Rock Paper Shotgun Article: Have You Played... It Came From The Desert!?
EDIT: Forgot to mention this classic has been available on PC for some time in the brilliant Cinemaware Classics ANThology - Along with the brilliant WINGS, Defender of the Crown, and Rocket Ranger!
I would also love a new Perfect Dark. Love both the original games and neither get the love they deserve. The original is often overlooked for the vastly inferior Goldeneye and Perfect Dark Zero was hated for reasons I could not grasp. Played 100's of hours of PDZ and it remains one my favorite FPS of all time.