Returnal seemed like it was going to be all wrong when it was first announced. Realistic character, story-heavy design, "traditional" combat viewpoint, AAA game aspirations, none of the arcadey stuff they've been known for for decades. And yet, once you play it, you not only get why Housemarque wanted to do this (especially after all the bad vibes about it being in financial trouble in the AAA Era, plus the cancelation of Stormdivers,) but why they were a good fit for making it happen. So I'm glad it worked out this way.
I don't really see Infamous being in that style. It's long-form gameplay with little defined combat loop, it's physical in its mechanics yet haphazard (your superpowers let you throw stuff around or knockback whatever, but there's rarely precision required,) enemy variety is largely people (or vampires) so the idea of finding depth in the enemies is hard to identify, storytelling and character building in Infamous is branching and would be a pain to work on unless you really loved that part of the project (even Sucker Punch only so-so invested in the Karma system) plus it takes priority over gameplay at times and just hasn't been Housemarque's style even as they go towards AAA, and overall, realistically, there's little of Returnal that matches the past 5 Infamouses (counting the DLCs) aside from that it has a third-person camera system.
Housemaque's skills are elsewhere, so no, I don't think they're a good match for that brand.