I was thinking about it, and there is so much that makes little sense with the plot when you think about it. I absolutely don't care, because I still love the movie and like that it doesn't explain things, but a few are:
1- Why the heck do they need to carry out the Voight Kampf test if they got photos of the escapes. You'd think they would already know those replicants are on the run, but we're supposed to assume they only find out after Leon shoots the other runner. But logically, why do a test? Get their ID, compare it to some data base. Wouldn't be surprised 2049 tries to explain this by saying Replicants are copies of real people, so they don't have unique faces.
2- If getting a positive means you can shoot them on sight, you'd think the blade runners would have the right search whoever they think might be one before putting them on the test so they don't get a laser shot to their face.
3- Why Deckard? What's so special about him? At this point they got people running around, they got their pictures, just broadcast some dangerous people are on the run, 5k reward, done. They're not trying to figure out if they are replicants anymore. If Deckard thinks he knows where they are, call the cops? Is the whole Blade Runner operation supposed to be secretive? It's clear cops know about it.
4- Why go see Tyrell? He apparently wants to validate that the Voight Kampf test works on nexus 6 models, but again not only does Deckard never use it on them, they have their IDs, no need for any test. You find them, you shoot them. Did he really think he was going to get to sit down with them and interview them, especially after Leon shot the other blade runner during an interview?
5- Tyrell basically tells Deckard "Hey, Rachel is a replicant indeed.", which was a secret, a new model too, yet when she essentially stops showing up for work, Tyrell reports it to the cops? It specifically says she has to be retired because she ran away, which means she wouldn't have to be if she hadn't. You'd think Tyrell would have just said "Your test doesn't work, she's real. Bye.", and layer up.