Looking good. Space, planets, and ships look great, character models seem good for BioWare standards (Cora's hair even moves!) but default male Ryder doesn't hold a candle to Shepard, Vanderloo looked just better and more unique even with the buzzcut.
As I thought the main story (aside from the premise) seems generic, whether it's weak or not we'll see but the worst part of the new Star Trek movies coming to mind is not encouraging. They said they were taking cues from Saren to develop Archon but judging by the trailer s/he seems like the most generic baddie ever, Corypheus style.
Crew seems very ME1-esque which is not bad, I never expected lots of variety at what's probably the beginning of a new trilogy.
Cat-lizard people look cool though.