Uncharted 2 opening it's probably one of my favorite starts in a game ever. I already played U1 and GA before U2, but that scenes made me feel uneasy. And I have that same feeling everytime I play through them.
My main concern against U3 (aside the fucking ship chapters which killed the game for me) is how "disconnected the story feels. It's like they decided the level first and Amy had to adapt the story to fill all those stages. The ship is the perfect example to show everything that was wrong in the game. Long, boring, story felt like a filler, lots of waves of enemies. And, even if this doesn't affect the whole game, the not so good shooting + the fact that everything is swinging the whole time really made me rage lol.
It's probably the only Uncharted game I'm sure I won't repeat on higher difficulties. I'm used to play everything on normal at first. I have GA platinum, beaten U2 in hard (sometime this year I'll go for crushing) and I want to revisit sometime U1 too. But 3? Never again, that game is bad for my health. If I want to have a heart attack sometime, I'll play that thing on crushing lol