Here are some games that continue to inspire me. Most of 'em are pretty old (comparatively speaking) but I keep coming back to them for one reason or another. I don't know if they'll "blow your mind" but I'd like to think there's a hook somewhere in there for most of these.
Gravity Bone - This is an amazing little vignette in game form. I've even seen it compared to a joke, complete with setup and punchline. It's a wonderful, wonderful little title and Brendon Chung continues to produce some great work.
The Passage - This one is oft-referenced, but for good reason. It also serves as a nice companion piece for Gravity Bone - both are experiences you only really
need to play through once, but are powerful enough that I think you'll come back.
Facade - Grace and Trip are having relationship trouble, and your actions will guide how their relationship continues. Games are all too often about shooting dudes in the face with discreet values for winning and losing. Facade is structured more like an improv drama with you serving to guide the AI actors. The text-based interface isn't perfect - it isn't even that good - but the idea is so simple and pure that I think it transcends its technical deficiencies.
Achron - An RTS about time travel. Not like, sending tanks back to fight in the Civil War, but a game where the manipulation of time is itself a mechanic. If you don't like the fact that your enemy has a better army than you, go back in time and have your tanks shoot his base up before those tanks can be made. But be aware - he can just as easily send his tanks back in time to prevent your tanks from ever succeeding. Just for the sheer mindfuckery of it all, I love this game.
Real Lives - If you ever wanted to feel really, really good about being a half-healthy literate person with a computer, play this game. You think unboxing an Unusual Hat in TF2 is unlikely? Try having a successful, long life in this simulation. On one hand I love this game because of its urgent social message, and on the other I love how well it highlights the ability of intricate systems to have awesome bugs.
I'll see if I can't think of any more later tonight, but this is what jumps immediately to mind.