I think the major difference is that in the previous games the good guys/bad guys were lined up along factions (the Borgias, the Pazzi, the Doge), and not nations. I can't speak for anyone else but my main worry is that the game is just going to be cheerleading the USA. I know that they've said a few times that it's not like that but if you look at ALL the PR so far that's how it's been. All they've shown is Connor killing British people, quotes from Washington's speeches (or whoever), VOs about freedom and liberty, the boxes have American flags on them and a durned evil Redcoat about to get scalped. And, you know, the reaction from a lot of people is basically what you'd expect: "yay, I can't wait to kill Redcoats", "I really hope in this game I can kill the bastard traitor Benedict Arnold!", etc.
Their justification has also been incredibly flimsy: "it's not about the USA because the USA didn't exist until 1781(?), it's a civil war". Do people in the US think it was a civil war? I'd be very surprised.
And to cut people off at the bridge, before they point out that the team is French-Canadian, I think that's completely irrelevant. They're making a product, they're making something which they want to sell, they're not making a work of art. And they clearly are worried that they're alienating people because they're incredibly keen to claim at every opportunity (such as that bizarre conference bit post-demo) that it's not a game about how the British are evil and the Americans are great.
Basically, I'll be very surprised if the game is something other than twelve hours of tedious Fuck-Yeah-America-ism. I'm more interested in the PSVita game.
If I were a betting man I'd put money on the final boss being travelling to England to kill George III at this point. I'm hoping, at least, that one of the followup games might be set during the French Revolution.
The reason I give a shit is that frankly this shit is overdone and tedious, and I'm not interested in plopping down £45 on a game that just informs me that America is the greatest country on earth because Freedom. If I wanted that I'd just watch GOP candidate speeches.