I gotta say... my wife and I have had several Dominion play sessions, and I just don't think it works that great for two.
I mean, it works okay. It's not like the 2P variant has to be shoe-horned into the game or anything. I just don't think the experience scales down to 2P very elegantly. Neither of us like playing Dominion 2P as much as Caracassonne or Lost Cities, which are our only other Eurogames.
- With just 2P it's very easy to keep a running score total in your head at all time. Yes this is possible with 3-4, but tougher. In 2P it's almost harder to NOT know what the score total is. This means we can know when to end / not end the game. Some might view this as a plus, but for us it makes the entire game more boring.
- Attack cards lose some of their oomph, and their value. A Thief in a 4P game gives you lots of opportunity to pick up some coins. But in 2P, not so much. Yet it still costs the same in 2P.
- With only 2P there are frequent delays as one of us finishes our turn before the other has finished reshuffling. With turns passing back and forth you are *literally* shuffling the entire time. No time to sit back, relax, eat a chip, etc. In our last session almost every turn a thief or spy would be laid and the other person had to say "hold on" and delay everything as they finished reshuffling.
- In 2P there is limited need to buy cards to react to your opponent. You only have one other deck strategy to counter. If your opponent doesn't buy militias, no need to buy libraries (or moats). If they don't buy thiefs, no need for moats or +coin actions.
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I have yet to play with more than 2, but from our 2P sessions I can see how a bigger group brings out the elegance of the game's design to a greater degree. More vying for desirable Actions, more tough decisions (if only one of four people is buying attacks, do you still stack moats?), etc. A friend is having a BG night next weekend and I hope to get some 4P Dominion going for the first time.
We're pretty spoiled by Caracassonne, which scales BRILLIANTLY from 2 - 6. The more I read about other games, the more it seems this is the exception, not the rule.