Some of the local yokel commercials...
Like Empire and their stupid jingle and the John Moore commercials with an overly peppy little chick who overenunciates every word she speaks. And, honestly if it was truth in advertising, they'd just come out and say "hey, if you're old, we're happy to take advantage of you."
I'm also kinda glad that Matress Mack isn't in as many commercials any more, because screaming furniture commercials are right there with screaming car commercials for being annoying as hell. Speaking of car commercials... Melissa Demontrond continues to creep me the fuck out every time she smiles... it's like watching an orca chew tobacco.
I guess if you're not from around here you don't appreciate those, but honestly those are the only ones I see because I otherwise FF through my DVR. I guess I have noticed that Velveeta commercial with Liquid Gold... yes... a lot recently. I wouldn't say it pisses me off. But it pisses my wife off because I then start saying it over and over again. Note I have also made a Skyrim character based on that guy.