Must listen:
CAGcast
In this podcast, I can actually hear the difference between the people on it (since they're only 2, never change, and have very different voices, VERY).
Also, because of that the podcast is far more personal, and most importantly: They don't always talk about video games. I mean, I read all the news here on GAF and on the websites, why would I want to hear it again in a podcast?
Also, the host lives in Tokyo, the other guy in New York. Since they don't see each other every day, they have a lot of interesting stuff to talk about on the podcast. One time they also let their wifes talk to eachother, I mean, I can never see that happening on 1upyours/IGN etc...