One I've had in mind for a potential reboot is to make the gameplay and atmosphere akin to Alien Isolation with a mix of Silent Hill.
Specifically speaking, I think it'd be beneficial to maybe lower the enemy count per area to a miniscule amount. In exchange, make the player vastly more vulnerable even by the survival-horror standard e.g. just maybe 1 - 2 non-heavy firearms and 1 or 2 melee weapons. Basically, classic RE but with the stakes raised higher. Survival becomes the quintessential aspect of the gameplay.
Also perhaps change the character into a role that's not a super expert secret agent anymore. Maybe a detective? As for enemies, I'd say something akin to the RE4 cultists sounds about right but again, more quality, less quantity.
Couple that with an atmosphere akin to PT and bob's your uncle.
(Then again, I also think this idea sounds a lot like a YouTuber type of horror game

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