Mass Effect: Andromeda's overdesigned UI isn't the best in terms of functionality (the sorting tabs are actually really nice though):
Also, for some reason, it shrinks the button icons for controllers, which is fucking stupid, since most people are going to be a few feet away from their TV.
XCOM 2 overall has good UI, but the health UI and subtitle display is godawful:
The health bar is made out of tiny pips that get smaller and smaller as health values increase, making it impossible to read how much health higher end enemies have. There's a reason people consider Numeric Health Display a must have mod.
The subtitle display box in the top right corner is fine on PC, but if you've got it hooked up to a smaller TV and are sitting a few feet away, that shit is unreadable... and there's no font size options.