If anything, gaming has taken its toll on my productivity at work. Whether that even qualifies as "ruining my life" is up for debate, but there has always been the risk that I could lose my job for coming in late after a long night of gaming.
I'm lucky in that my GF, while she isn't an avid gameplayer, enjoys games like Tetris, Bejeweled, Zuma, Bookworm, Nintendogs, Yoshi's Cookie, Puzzle Bobble, et al., and is curious about the games I play. She's fascinated by Bemani games, and always keeps an open mind about the games I play, and likes seeing at least bits and pieces of them and talking about why I like them.
I have to admit that I don't reciprocate that kind of interest when she's talking about make-up and shoes, so in that respect, I'm pretty blessed... lots of my friends have GFs and wives who would rather they trash all their videogame systems and games than allow them to continue enjoying an aspect of their life that has brought them so many good memories. Some have given in to that, which I think is sad.