I am terrible with this this kind of thing when it comes to health potions, etc.
I'll literally (in games were you can't easily refill them) re-load a save instead and try to do better instead of wasting a potion.
However usually what happens is I'll end up getting to the end of a game with a toooooon of saved up potions and things because I kept putting them off "in case I REALLY needed them" but ended up never using them hardly.
It's funny, but I don't actually do this in games like Dark Souls/Bloodborne (which are known to be quite difficult vs say, Fallout), because of how the potions refill when you go to a bonfire or drop from enemies, which is a LIFESAVER For me, no potion hording in those games.