Zuckerberg being the template of Luthor would make sense to me. Who else would have the ego to challenge Superman than a man who built a vast business empire at a ridiculously young age. Who knows, maybe the youthful energy/tech culture would bring some of the mad scientists quirks back to the character.
Fuck that.
Lex is a dude who earned everything he got, even if not legally. The American Dream spirit personified. Not a counter culture douche. He's a dude who wears a suit.
The only way I can imagine a Zuckerberg type portrayal working is if Lex wanted to be Superman's friend, and Superman doesn't reciprocate that. Like a rich Jimmy Olsen. Lex is the dude who hates aliens because they represent the end point of human endevour.