"That whole idea for me is a sickening thing, it's always just made me sick," Depp told reporters in Berlin on Sunday before the world premiere of his latest film Mortdecai.
"I've been very lucky to play on friends' records and it's still going. Music is still part of my life.
"But you won't be hearing The Johnny Depp Band. That won't ever exist."
Depp, an accomplished guitar player, has recorded with the likes of Oasis and Marilyn Manson in the past and he performed on stage with the latter at the Hollywood's Roxy Theatre in November.
Scarlett Johansson, Russell Crowe, Robert Downey Jnr and Depp's Mortdecai co-star Gwyneth Paltrow are among those whose musical endeavours have gained notoriety through their acting fame.
Depp, though, is content in being a low-key musician.
"The kind of luxury now is, anybody with a certain amount of of success, if you have a kind of musical being, you can go out and start a band and capitalise on your work in other areas," the Pirates of the Caribbean star said.
"But I hate the idea, 'come see me play the guitar because you've seen me in 12 movies'."
"It shouldn't be (that way). You want the people who are listening to the music to only be interested in the music."
