Papa John's is just completely awful. Terrible, terrible pizza.
Little Caesar's is a $5 pizza. It's not that great, but it is for what you get.
Domino's and Pizza Hut are good, but just slightly too pricey that you'd rather just eat at somewhere a little better for not that much more money. Same with Godfather's, though I like Godfather's a little more.
Marco's pizza is the GOAT pizza chain. Just completely delicious. It's the only pizza chain that can at all compete with non-chains and local chains. It's so good. Though, to be fair, one only opened up around here recently.
Happy Joe's is a good local one in the Midwest. In the Quad Cities, Wise Guy's and Pizza Shack are also good. Villa Pizza and Sbarro's aren't good by the slice, but great if you just order a whole pizza. But then you got to go to the mall to get it, and no one wants to do that.
These threads always make me laugh. OP asks for Nationwide chain, people eventually start posting some little chain that has 3 location's in a tiny town in Iowa.
Hey, Iowa does have the best pizza! We got Happy Joe's, we got Wise Guys, we got pizza in our grocery stores (Hyvee), hell we even got pizza at our gas stations (Casey's). And it's actually good! Hell, Quad City Style Pizza is actually even named after us. And it's the bomb.