Anecdotally speaking, I was telling my friends about the 3DS last night who grew up as avid fans of Zelda and nintendo gamesl. I told them about how it had a 3D screen that didn't need glasses and that they were remaking OOT in 3D and they were instantly Hyped for the system.
Really though, all these guys do is play wow and dota, and a few apps on their iPhone 4's when they are in a situation where they need to kill a few minutes, so I don't see them jumping on a single purpose device like the 3DS. I could probably hype them in to buying it, and they would probably buy OOT and dink around, but honestly they would probably just let it collect dust after that because of the WoW/iPhone combo.
As for my co-workers they will absolutely never touch this device with the exception of one of my fellow game designers. Pretty much everyone else here either plays starcraft, has an iPhone 4, or doesn't engage in handheld gaming, period.
Even with all that, I think its unfair to write off the 3DS in any way - I have completely fallen in love with Nintendo again over the past year and the quality of experiences I've had on their two systems recently have completely blown away anything I've experienced on an i device.