it's entirely possible that they could have one core team focused on tyranny and then another, with Tim Cain/Leonard heading it, focused on concepting and starting development on a new Vampire: TM game.
I mean, it would be borderline crazy NOT to. Vampire: TMB is regarded as one of the best rpgs of all time now and almost any forum you even bring it up people flock to talk about how awesome and great it is and how they wish there was something else like it.
For Paradox to have such a close relationship to Obsidian who has two of the main trokia guys there it'd be an extreme missed opportunity to not do that. I mean it's the most well-known "White wolf" video game out there now.