I doubt it. Rockstar North seems to have a good degree of creative control, and I don't think Take 2 is in much of a position to delay shipping a GTA game once it is ready. They'll probably be more careful about what they list under the ESRB rating, though.
Given that money is more improtant than ever to TT, they aren't going to want Rockstar to take anything out at all. And Sam and Dan have already made it clear that they make games like this and make no apologies for it.