I'm left handed.
I play games with the default control scheme.
left stick movement, right stick camera.
or with m/kb, I use my right hand. Left handed mice feel awful to me.
Using the left side of the 3DS while using your right hand for the stylus is impossible.. I remember trying to play COD4 DS... lol what a joke.
But being lefty, I recently just found out I have been at a ridiculous disadvantage in multiplayer games, especially FPS (Mostly Halo). Its just so hard to control the right stick smootly (or mouse) as I can do with my left hand. I wish I was righty
Also, playing Counter-Strike is RIDICULOUS while being lefty and using your right hand to aim.. which I have used my whole life. So most of you might say to try and use a different control scheme or use a left handed mouse. but Ive been doing this way my whole life and I just cant change it.
Also, FUCK THE GUITAR HERO WAMMY BAR, no way could I hold the guitar lefty and use the wammy bar.
tl:dr everything is designed for righty's, Im lefty. Makes it hard to aim well. just found out. wish I was righty.