Please.
Shrink up that story. It was very long and unwieldy and ultimately not all that involving or effective. Thankfully the atmosphere, visuals, and gameplay more than made up for it.
Stop fucking with Ripleys. Done with Ripleys. Enough. You already found a new location. Find a new protagonist. One not related to Ellen Ripley, the single most important person in the whole universe.
Make the Aliens less rubberbandy and/or clingy, but ALSO make them more like the Aliens in the first 3 movies, and not like the ones in the fourth. The Aliens in Isolation were the clumsy, roaring, grunting ones from Resurrection, not the slick, silent, tricky ones from the first few movies.
I love love love Isolation, and I hope if they follow it up, they take the chance to improve on what they've got, and not abandon it for the 30,000th fuckin shooter these games have seen.