My one concern about the likelihood of Sony continuing Uncharted is that The Lost Legacy didn't seem to do that well commercially.
They may be worried about how well the franchise would do without Nathan Drake at the helm.
Personally I like Chloe, but was really irritated by them pretending she was Indian all along. They also made her much less sexy, which was her main appeal lol. It was practically her defining characteristic.
But I really don't like Nadine and the general, tedious, "girl power" vibe. She's got no personality whatsoever. Literally anyone else from the series would've been preferable as a sidekick. They really didn't do the game's chances any favours going down that route.
If it were up to me I'd probably do a sequel with Nate as the lead, in some kind of plot to rescue Elena or Sully or someone. You could then introduce some other character he works with who you could perhaps transfer control to
So you'd be riding off the popularity of Nate but properly setting up the series for the future too. There's nothing really in the last game that would preclude that as a coherent narrative.