7th Saga for SNES had the stats tweaked with by Enix USA to make the game much more difficult than Elnard for the Super Famicom. After a while I grew to like the challenge, but compared to my playthrough of the import it was insanely difficult. My first playthrough I got stuck in the final world map area and couldn't even beat a random encounter to gain levels. Had to restart the entire game and ended up beating it with careful planning.
Kinda random, but they also changed the loud synthesized door-opening sound effect in the first town's castle to the generic menu clicking sound. Kind of obscure thing to change, but they did. Maybe on accident when they were messing with the game? I don't know or particularly care.
And holy shit at Working Designs' tweaking of Exile 2. Y'all ruined the game for me to the point of making it practically impossible.