Do you play VR games? The Splinter Cell gameplay would transfer almost perfectly into VR.
Interactive objects to be thrown. Be it at guards, for a distraction, to trip alarms, traps or even break lights.
Guard interactions and takedowns. Grab a guard from behind, disarm them, interrogate them, grab them from ledges, push them out of windows, etc.
Further into interrogations: Choke the guards out, hold knife up, pull out gun to shoot while having them as human shield, etc.
Doors: grabbing door handles and opening door slowly or bashing door open. Using camera underneath door to check other side.
Other things like flipping light switches, pulling goggles down, grabbing guns from side and back holsters, breaking glass on door or window to unlock, etc.
Holding guards up to retinal scanners, hand scanners etc. Carrying bodies, cutting through fabric, and so on.
These are just a few things that immediately come to mind. There's plenty more that could work.
VR worked great for Hitman actually,. The PSVR version is better than the PC version when it came to control implementation, but the overall experience is awesome in VR.