Games without auto save deserve to burn in hell. Save points are a ridiculous gameplay element
I think I've lost just as much progress to bugged or stupid autosaves as I have with manual. Its horrible getting autosaved in a near unwinnable situation.
My worst loss though was thanks to GFWL and its awful save system. Batman AA randommly deleted my saves at about 10 hours and I lost about 20 hours on GTA4 as I backed up the save folder when moving stuff from a dying hard drive but didn't realise that GFWL wont accept them unless you back up your profile with it(and do a bunch of other steps to fool it into accepting them).