I think a lot of people from the non-American English-speaking world who have been to the States for any length of time have experience of making a sarcastic or ironic joke at an American and having them take it seriously, while anywhere else in the world it would be taken as a joke.
American: Where are you from?
Brit: Some little backwater town where people eat their young.
American: Oh my God! That's terrible!
Of course, we might be missing the joke that the response is ironic.
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Back on the OP, I'll have to check out Wilfred. I liked the clips but it doesn't appear to be out on DVD here.