Souls series - I know they won't all be as good as the Souls games, but there's plenty of room to experiment with the formula.
God of War - People will say GOW had its fair share of clones, but IMO none of them are even close to as good. I would like a character action game with a nice balance of story, puzzles, traversal, and combat, with great production values. Add to that the novelty that would come with a new game world and characters, and you've got me. Bonus: Naughty Dog level story and writing. GOW1 had very good storytelling and acting relative to other action games in 2005, but by the time GOW3 rolled out, they had been surpassed, and they need to step it up.
Resident Evil 4 - Dead Space was a refreshing evolution of the RE4 formula, and I think there's plenty of room for deliberately paced 3rd person shooter action/horror games. Even if the length and ingenuity of RE4 is unlikely to be matched, I'd still be very happy with a solid-feeling, no-filler, game that was only 2/3s the length.
Super Metroid or Symphony of the Night - I know metroidvanias are a dime a dozen in the indie space, but I have yet to play one that has made me feel like either of those two games (or one that embraces ALL of the essential design philosophies of the genre). Maybe that's more about me, maybe I'll never feel that way about a game again, but I want to play as many as possible to find
Bayonetta/DMC/Ninja Gaiden - I don't care which you copy, just make more character action games, you assholes!