This one is a little interesting. The artwork in the middle, in between the two columns, is a re-creation based on what we could make out. The surrounding part is the original ornament, rephotographed at a much higher resolution. In the original ornament, the top middle section contained a little figurine set of the crucifixion, and the bottom middle section was a statue of what seems to be a scribe (you can see this in an earlier version that Albert shared a while back:
http://www.re4hd.com/wp-content/gallery/0041-sewer-and-water-room/204A.jpg).
So, for the top portion, even in Capcom's edited version it seemed like the crucifix scene was retained, and that a woman looking up to the sky in a bit of despair or fear was added. And for the bottom it seems there's a similar woman looking up. Based on being able to figure that out, we found suitable artwork to work with and it all came together like you see above.
And that's about it!