Telltale's Walking Dead games maybe?
metal gear rising
dead rising i guess?
Northern part of GTA V?
It's an old one, but Redneck Rampage.
The upcoming Days Gone is supposed to be Oregon, right? Or am I just thinking that because of where the developers are located?
The forthcoming Detroit: Become Human
Deadly Premonition. It's supposed to a Pacific Northwest town, but I think it fits the bill.
Alan Wake
Mafia 3... what with the country full of racial tension and corrupt racist people running things. Mafia 3 is the freshest most modern take on the current climate of tension!
You're looking for Kentucky Route Zero.Not middle America, but you just have me the idea of a southern-America inspired fantasy game, ala Big Fish. That'd be dope.