Been playing this on Xbox over the last month and have completed it (and Separate Ways) except for the shooting gallery achievement which I am doubtful I can get but I will go back and give it another try.
It is a good game but has some infuriating flaws. It has a habit of frequently snatching the camera away from you and making you look in the wrong direction and then has you fighting with it to regain control. Movement is clunky and animations have to complete fully before you can start moving again, which can lead to being grabbed or killed on higher difficulties. Also every cutscene makes you wait 1-2 seconds before it will respond to the skip button, so you will often press it 2-3 times before it works. How does this get past play testers. I regularly wish my character would get moving when I tell them to, but instead they stay there frozen to the spot or flinch which results in another cheap death.
Professional NG S+ is brutally difficult and the previous advice in this thread to use door skips no longer works as it was patched out. I did it on Separate Ways but haven't tried and probably won't on the main game, I'd be more likely to if there was an achievement.
This would benefit from a speedrun mode where all cutscenes were removed, should also have animation cancelling which would make gameplay a lot more fluid.
edit - I did do NG S+ on the main game after all.