I've said this before but as far as I'm concerned (and admittedly in part due to fan bias), Gundam is the most commercially viable anime property you've got in terms of a Hollywood adaptation. I mean, you've already got one of easiest pitch in the world to execs and audiences -- "It's Transformers/Star Wars in the Milky Way". Obviously, it's not gonna be as simple as that, but it's already got that solid base accessibility-wise.
This is especially since, around here in Vancouver at least, I've noticed that the average joe actually recognizes the property pretty well, even if their only experience with it was Wing in the late 90s. To add to that, the series itself has got some plenty of YA trimmings to work with if you want to cater to that crowd and enough milk in its source material to franchise the shit out of it.
However, and I've mentioned some of this in earleir threads, you need some key conditions to make it work well commercially.
You need a both good creative AND marketing team to set it apart from everything else. As other mentioned, GitS suffered not just because of the controversy, it suffered because "ScarJo doing more actiony sci-fi shit. What's new?" Same thing for the graveyard of YA adaptations after Hunger Games. You're gonna need find a fresh new selling point and frame outside of the basic pitch and make sure you hit the mark on that.
On that point of over-saturation and familiarity, Transformers and the Star Trek films need to be dead. In fact, they need to be dead now. Why? Because that big shark you have to beat called Star Wars has a planned movie hiatus post-Episode IX and god knows how long that's gonna last. It needs to take advantage of that.
