There are far to many games coming out this Fall/Holiday. Only a handful I think will see any major success. It's just a matter of how much money people will have and if certain titles will cannibalize each other.
Darksiders 2 I think will do poorly. I think the choice is this or AC3 even though AC3 doesn't come out until October. Does one spend the money to buy DS2 now at full price or wait until AC3 comes. It's clear which will be the more popular game and the showing of it at E3 could have sealed the deal for a LOT of people. I don't not feel confident in DS2 and part of why I'm waiting in general (not even for the Wii U version) to see how quickly the price on that drops.
Then there is the issue of the Wii U. I would expect the launch of a new console would hurt sales of games around that time. That's a lot of money to invest and early adopters would be people across all systems. I would expect the same when the PS4 and 720 launch as well. Only certain titles would be able to withstand that type of event during the launch months. Halo 4, Black Ops 2, AC3 and maybe RE6 should be fine for example when it comes to big successes. Everything else that isn't in that group or Wii U launch game could take a beating. Launch games as a result, some of them, would see unexpected success (the type certain games would normally not get).
For Wii U launch games I see the following doing okay with varying degrees of success..
New Super Mario Bros U
Zombi U
Black Ops 2 (if it's a launch game)
Just Dance 4
Pikmin 3
Assassin's Creed 3 could really go either way. I think it will just do okay but be very close to bomb unless somethings sets it apart from the others.
Edit: Is the hype for Borderlands 2 really that high?